Intermediate Pharmacokinetics and Pharmacodynamics
PHA 6935 Intermediate Pharmacokinetics and Pharmacodynamics

Credits

This is a 3-credit course.

Description

Intermediate Pharmacokinetics and Pharmacodynamics is a 3-credit course that provides students with an in-depth understanding of the theoretical concepts as well as hands-on applications in population pharmacokinetic/pharmacodynamic (PK/PD) modeling using both continuous and non-continuous data. Upon completion of the course, students will be able to understand nonlinear mixed-effect modeling theory and implementation, data formatting, population PK/PD model development as well as evaluation criteria, and Monte Carlo simulation. This course aims to expose students to multiple population PK/PD software platforms, including Monolix, NONMEM and Phoenix.

Topics

Week Topic
Week 1: Module 0 Course Overview
Week 2: Module 1a Population PK: Compartmental Models, Model Evaluation
Week 3: Module 1b Population PK: Covariate Analysis, Monte Carlo simulation
Week 4: Module 2 Population PK: Separating Between Subject Variability and Inter-Occasion Variability
Week 5: Module 3a Population PK: Introduction to NONMEM
Week 6: Module 3b Population PK: Parent – Metabolite
Week 7: Module 3c Population PK: Special Populations
Week 8: Module 4 Population PK: Dose Selection
Week 9: Exam #1 Covers Modules 1-4
Week 10: Module 5a Population PK/PD: Continuous; Direct Effects
Week 11 Spring Break
Week 12: Module 5b Population PK/PD: Continuous; Indirect Response Models
Week 13: Module 6 Population PK/PD: Continuous; Irreversible Effects
Week 14: Module 7a Population PK/PD: Continuous; Categorical Response
Week 15: Module 7b Population PK/PD: Continuous; Count Data
Week 16: Module 7c Population PK/PD: Continuous; Time-to-Event
Week 17: Exam #2 Covers Modules 5-7