Credits
This is a 3-credit course.
Description
Population Pharmacokinetics and Pharmacodynamics is a 3-credit course that provides students with an in-depth understanding of the theoretical concepts as well as hands-on applications in population pharmacokinetic/pharmacodynamic (PK/PD) modeling using both continuous and non-continuous data. Upon completion of the course, students will be able to understand nonlinear mixed-effect modeling theory and implementation, data formatting, population PK/PD model development as well as evaluation criteria, and Monte Carlo simulation. This course aims to expose students to multiple population PK/PD software platforms, including Monolix, Pumas and Phoenix.
Topics
| Week | Topic |
|---|---|
| Week 1: Module 0 | Course Overview |
| Week 2: Module 1a | Compartmental Models, Model Evaluation |
| Week 3: Module 1b | Covariate Analysis, Monte Carlo simulation |
| Week 4: Module 2 | Separating Sources of Variability |
| Week 5: Module 3a | Nonlinear PK |
| Week 6: Module 3b | Parent – Metabolite |
| Week 7: Module 3c | Special Populations |
| Week 8: Module 4 | Dose Selection |
| Week 9: Exam #1 | Modules 1-4 |
| Week 10: Module 5a | Direct Effects |
| Week 11 | Spring Break |
| Week 12: Module 5b | Indirect Response Models |
| Week 13: Module 6 | Disease Progression Models |
| Week 14: Module 7a | Categorical Response |
| Week 15: Module 7b | Count Data |
| Week 16: Module 7c | Time-to-Event |
| Week 17: Exam #2 | Modules 5-7 |