Population Pharmacokinetics and Pharmacodynamics
PHA 6122 Population Pharmacokinetics and Pharmacodynamics


This is a 3-credit course.


Population Pharmacokinetics and Pharmacodynamics is a 3-credit course that provides students with an in-depth understanding of the theoretical concepts as well as hands-on applications in population pharmacokinetic/pharmacodynamic (PK/PD) modeling using both continuous and non-continuous data. Upon completion of the course, students will be able to understand nonlinear mixed-effect modeling theory and implementation, data formatting, population PK/PD model development as well as evaluation criteria, and Monte Carlo simulation. This course aims to expose students to multiple population PK/PD software platforms, including Monolix, Pumas and Phoenix.


Week Topic
Week 1: Module 0 Course Overview
Week 2: Module 1a Compartmental Models, Model Evaluation
Week 3: Module 1b Covariate Analysis, Monte Carlo simulation
Week 4: Module 2 Separating Sources of Variability
Week 5: Module 3a Nonlinear PK
Week 6: Module 3b Parent – Metabolite
Week 7: Module 3c Special Populations
Week 8: Module 4 Dose Selection
Week 9: Exam #1 Modules 1-4
Week 10: Module 5a Direct Effects
Week 11 Spring Break
Week 12: Module 5b Indirect Response Models
Week 13: Module 6 Disease Progression Models
Week 14: Module 7a Categorical Response
Week 15: Module 7b Count Data
Week 16: Module 7c Time-to-Event
Week 17: Exam #2 Modules 5-7